A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation.

ABSTRACT:

Background

Testicular dysgenesis syndrome (TDS) is a common disease that links testicular germ cell cancer, cryptorchidism and some cases of hypospadias and male infertility with impaired development of the testis. The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population.

Methods

To identify genetic variants that span the four TDS phenotypes, the authors performed a genome-wide association study (GWAS) using Affymetrix Human SNP Array 6.0 to screen 488 patients with symptoms of TDS and 439 selected controls with excellent reproductive health. Furthermore, they developed a novel integrative method that combines GWAS data with other TDS-relevant data types and identified additiona

SUBMITTER: Dalgaard MD 

PROVIDER: S-EPMC3284313 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature