HTreeQA: Using Semi-Perfect Phylogeny Trees in Quantitative Trait Loci Study on Genotype Data.

ABSTRACT: With the advances in high-throughput genotyping technology, the study of quantitative trait loci (QTL) has emerged as a promising tool to understand the genetic basis of complex traits. Methodology development for the study of QTL recently has attracted significant research attention. Local phylogeny-based methods have been demonstrated to be powerful tools for uncovering significant associations between phenotypes and single-nucleotide polymorphism markers. However, most existing methods are designed for homozygous genotypes, and a separate haplotype reconstruction step is often needed to resolve heterozygous genotypes. This approach has limited power to detect nonadditive genetic effects and imposes an extensive computational burden. In this article, we propose a new method, HTreeQA, tha

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC3284325 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature