Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype.

ABSTRACT: Basal cell carcinomas (BCCs) are the most common cancers in the United States. The histologic appearance distinguishes several subtypes, each of which can have a different biologic behavior. In this study, global miRNA expression was quantified by high-throughput sequencing in nodular BCCs, a subtype that is slow growing, and infiltrative BCCs, aggressive tumors that extend through the dermis and invade structures such as cutaneous nerves. Principal components analysis correctly classified seven of eight infiltrative tumors on the basis of miRNA expression. The remaining tumor, on pathology review, contained a mixture of nodular and infiltrative elements. Nodular tumors did not cluster tightly, likely reflecting broader histopathologic diversity in this class, but trended toward forming a

SUBMITTER: Heffelfinger C 

PROVIDER: S-EPMC3284335 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature