Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas.

ABSTRACT:

Background

Lung cancer represents the most frequent cause of death for cancer. In non-small cell lung cancer (NSCLC), which accounts for the vast majority of this disease, only early detection and treatment, when possible, may significantly affect patient's prognosis. An important role in NSCLC malignancy is attributed to the signal transduction pathways involving PI3Kinase, with consequent activation of the AKT family factors. The serum and glucocorticoid kinase (SGK) factors, which share high structural and functional homologies with the AKT factors, are a family of ubiquitously expressed serine/threonine kinases under the control of cellular stress and hormones. SGK1 is the most represented SGK member.

Methods

By means of immunohistochemistry and quantitative real-time PC

SUBMITTER: Abbruzzese C 

PROVIDER: S-EPMC3284423 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature