Adjuvant chemotherapy for resected non-small-cell lung cancer: future perspectives for clinical research.

ABSTRACT: Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guidelines, many questions are still open. Among them, it should be acknowledged that the treatment for stage IB disease has shown so far a limited (if sizable) efficacy, the role of modern radiotherapies requires to be evaluated in large prospective randomized trials and the relative impact of age and comorbidities should be weighted to assess the reliability of the trials' evidences in the context of the everyday-practice. In addition, a conclusive evidence of the best partner for cisplatin is currently awaited as well as a deeper investigation of the fading effect of chemotherapy over

SUBMITTER: Bonomi M 

PROVIDER: S-EPMC3284429 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature