Acute response of peripheral blood cell to autologous hematopoietic stem cell transplantation in type 1 diabetic patient.

ABSTRACT:

Objective

Autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approach that can improve β cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved.

Design and methods

We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute responses in peripheral blood for lymphocyte subpopulation as well as for genomic expression profiling at the six-month follow-up.

Results

We found six patients obtained insulin free (IF group) and three remained insulin dependent (ID group); C-peptide production was significantly higher in IF group compared to ID group. The acute responses in lymphocytes at six-month follow-up include declined CD3(+)CD4(+

SUBMITTER: Zhang X 

PROVIDER: S-EPMC3285188 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature