Discovering dysfunction of multiple microRNAs cooperation in disease by a conserved microRNA co-expression network.

ABSTRACT: MicroRNAs, a new class of key regulators of gene expression, have been shown to be involved in diverse biological processes and linked to many human diseases. To elucidate miRNA function from a global perspective, we constructed a conserved miRNA co-expression network by integrating multiple human and mouse miRNA expression data. We found that these conserved co-expressed miRNA pairs tend to reside in close genomic proximity, belong to common families, share common transcription factors, and regulate common biological processes by targeting common components of those processes based on miRNA targets and miRNA knockout/transfection expression data, suggesting their strong functional associations. We also identified several co-expressed miRNA sub-networks. Our analysis reveals that many miRN

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC3285207 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature