Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis.

ABSTRACT:

Objectives

This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis.

Background

Lp-PLA₂ has emerged as a potential therapeutic target in coronary heart disease. Data supporting Lp-PLA₂ are indirect and confounded by species differences; whether Lp-PLA₂ is causal in coronary heart disease remains in question.

Methods

We examined inflammatory regulation of Lp-PLA₂ during experimental endotoxemia in humans, probed the source of Lp-PLA₂ in human leukocytes under inflammatory conditions, and assessed the relationship of variation in PLA2G7, the gene encoding Lp-PLA₂, with coronary artery calcification.

Results

In contrast to circulating tumor necrosis factor-alpha and C-react

SUBMITTER: Ferguson JF 

PROVIDER: S-EPMC3285416 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature