Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity.

ABSTRACT:

Background

Obesity is known to be associated with higher risks of cardiovascular disease, metabolic syndrome, and diabetes mellitus. Thyroid-stimulating hormone (TSHR) is the receptor for thyroid-stimulating hormone (TSH, or thyrotropin), the key regulator of thyroid functions. The expression of TSHR, once considered to be limited to thyrocytes, has been so far detected in many extrathyroidal tissues including liver and fat. Previous studies have shown that TSHR expression is upregulated when preadipocytes differentiate into mature adipocytes, suggestive of a possible role of TSHR in adipogenesis. However, it remains unclear whether TSHR expression in adipocytes is implicated in the pathogenesis of obesity.

Methods

In the present study, TSHR expression in adipose tissues fro

SUBMITTER: Lu S 

PROVIDER: S-EPMC3285521 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature