Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis.

ABSTRACT: Dendritic cells (DCs) as professional antigen-presenting cells play an important role in the initiation and modulation of the adaptive immune response. However, their role in the innate immune response against bacterial infections is not completely defined. Here we have analyzed the role of DCs and their impact on the innate anti-bacterial host defense in an experimental infection model of Yersinia enterocolitica (Ye). We used CD11c-diphtheria toxin (DT) mice to deplete DCs prior to severe infection with Ye. DC depletion significantly increased animal survival after Ye infection. The bacterial load in the spleen of DC-depleted mice was significantly lower than that of control mice throughout the infection. DC depletion was accompanied by an increase in the serum levels of CXCL1, G-CSF, IL-

SUBMITTER: Autenrieth SE 

PROVIDER: S-EPMC3285606 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature