HumMeth27QCReport: an R package for quality control and primary analysis of Illumina Infinium methylation data.

ABSTRACT:

Background

The study of the human DNA methylome has gained particular interest in the last few years. Researchers can nowadays investigate the potential role of DNA methylation in common disorders by taking advantage of new high-throughput technologies. Among these, Illumina Infinium assays can interrogate the methylation levels of hundreds of thousands of CpG sites, offering an ideal solution for genome-wide methylation profiling. However, like for other high-throughput technologies, the main bottleneck remains at the stage of data analysis rather than data production.

Findings

We have developed HumMeth27QCReport, an R package devoted to researchers wanting to quickly analyse their Illumina Infinium methylation arrays. This package automates quality control steps by generat

SUBMITTER: Mancuso FM 

PROVIDER: S-EPMC3285701 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature