Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study.

ABSTRACT:

Objective

To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes.

Design

Population based cohort study with linked data from Medicaid, Medicare, the Minimum Data Set, the National Death Index, and a national assessment of nursing home quality.

Setting

Nursing homes in the United States.

Participants

75,445 new users of antipsychotic drugs (haloperidol, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone). All participants were aged ≥ 65, were eligible for Medicaid, and lived in a nursing home in 2001-5.

Main outcome measures

Cox proportional hazards models were used to compare 180 day risks of all cause and cause specific mortality by individual drug, with propensity score adjus

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC3285717 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature