Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age.

ABSTRACT: The p53 DNA damage response attenuated with age and we have evaluated downstream factors in the DNA damage response. In old animals p21 protein accumulates in the whole cell fraction but significantly declines in the nucleus, which may alter cell cycle and apoptotic programs in response to DNA damage. We evaluated the transcriptional response to DNA damage in young and old and find 2692 genes are differentially regulated in old compared to young in response to oxidative stress (p<0.005). As anticipated, the transcriptional profile of young mice is consistent with DNA damage induced cell cycle arrest while the profile of old mice is consistent with cell cycle progression in the presence of DNA damage, suggesting the potential for catastrophic accumulation of DNA damage at the replication fo

SUBMITTER: Simon K 

PROVIDER: S-EPMC3285901 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature