Cancer risk among patients with myotonic muscular dystrophy.

ABSTRACT:

Context

Myotonic muscular dystrophy (MMD) is an autosomal-dominant multisystem neuromuscular disorder characterized by unstable nucleotide repeat expansions. Case reports have suggested that MMD patients may be at increased risk of malignancy, putative risks that have never been quantified.

Objective

To quantitatively evaluate cancer risk in patients with MMD, overall and by sex and age.

Design, setting, and participants

We identified 1658 patients with an MMD discharge diagnosis in the Swedish Hospital Discharge Register or Danish National Patient Registry between 1977 and 2008. We linked these patients to their corresponding cancer registry. Patients were followed up from date of first MMD-related inpatient or outpatient contact to first cancer diagnosis, death, emi

SUBMITTER: Gadalla SM 

PROVIDER: S-EPMC3286183 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature