Involvement of purinergic signaling on nitric oxide production by neutrophils stimulated with Trichomonas vaginalis.

ABSTRACT: Trichomonas vaginalis is a parasite from the human urogenital tract that causes trichomonosis, the most prevalent non-viral sexually transmitted disease. The neutrophil infiltration has been considered to be primarily responsible for cytological changes observed at infection site, and the chemoattractants can play an important role in this leukocytic recruitment. Nitric oxide (NO) is one of the most widespread mediator compounds, and it is implicated in modulation of immunological mechanisms. Extracellular nucleotides and nucleosides are signaling molecules involved in several processes, including immune responses and control of leukocyte trafficking. Ectonucleoside triphosphate diphosphohydrolase members, ecto-5'-nucleotidase, and adenosine deaminase (ectoADA) have been characterized in T

SUBMITTER: Frasson AP 

PROVIDER: S-EPMC3286535 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature