Conformational analyses of thiirane-based gelatinase inhibitors.

ABSTRACT: SB-3CT is a thiirane-containing inhibitor of the gelatinase class of matrix metalloprotease enzymes. In support of the mechanistic study of this inhibition, the conformational analyses of SB-3CT (and of two methyl-substituted derivatives) were undertaken using X-ray crystallography and molecular dynamics simulation.

SUBMITTER: Lee M 

PROVIDER: S-EPMC3286628 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature