Three-gene molecular diagnostic model for thyroid cancer.

ABSTRACT:

Background

The preoperative diagnosis of thyroid nodules primarily depends upon fine needle aspiration (FNA) cytology. However, up to 25% of FNA samples have associated "suspicious or indeterminate", but not diagnostic cytologic reports, resulting in difficulty deciding appropriate clinical management for these patients. We hypothesize that the use of molecular markers as an adjunct to FNA cytology can improve the distinction of benign from malignant nodules that have associated suspicious or indeterminate cytology.

Methods

Using microarray analysis, we previously identified and reported on 75 genes useful in the distinction of benign versus malignant thyroid nodules. In the present study, we have further validated the expression of 14 of these markers in a large number of t

SUBMITTER: Prasad NB 

PROVIDER: S-EPMC3286810 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature