The characteristics of the synonymous codon usage in hepatitis B virus and the effects of host on the virus in codon usage pattern.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection is one of the main human health problem and causes a large-scale of patients chronic infection worldwide.. As the replication of HBV depends on its host cell system, codon usage pattern for the viral gene might be susceptible to two main selections, namely mutation pressure and translation selection. In this case, a deeper investigation between HBV evolution and host adaptive response might assist control this disease.

Result

Relative synonymous codon usage (RSCU) values for the whole HBV coding sequence were studied by Principal component analysis (PCA). The characteristics of the synonymous codon usage patterns, nucleotide contents and the comparison between ENC values of the whole HBV coding sequence indicated that the interact

SUBMITTER: Ma MR 

PROVIDER: S-EPMC3287100 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature