MiRNA signature associated with outcome of gastric cancer patients following chemotherapy.

ABSTRACT:

Background

Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA expression is dysregulated in cancer. In order to identify miRNA signatures for gastric cancer and for predicting clinical resistance to cisplatin/fluorouracil (CF) chemotherapy, a comprehensive miRNA microarray analysis was performed using endoscopic biopsy samples.

Methods

Biopsy samples were collected prior to chemotherapy from 90 gastric cancer patients treated with CF and from 34 healthy volunteers. At the time of disease pro

SUBMITTER: Kim CH 

PROVIDER: S-EPMC3287139 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature