Protein docking prediction using predicted protein-protein interface.

ABSTRACT:

Background

Many important cellular processes are carried out by protein complexes. To provide physical pictures of interacting proteins, many computational protein-protein prediction methods have been developed in the past. However, it is still difficult to identify the correct docking complex structure within top ranks among alternative conformations.

Results

We present a novel protein docking algorithm that utilizes imperfect protein-protein binding interface prediction for guiding protein docking. Since the accuracy of protein binding site prediction varies depending on cases, the challenge is to develop a method which does not deteriorate but improves docking results by using a binding site prediction which may not be 100% accurate. The algorithm, named PI-LZerD (using P

SUBMITTER: Li B 

PROVIDER: S-EPMC3287255 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature