Integrative analysis workflow for the structural and functional classification of C-type lectins.

ABSTRACT:

Background

It is important to understand the roles of C-type lectins in the immune system due to their ubiquity and diverse range of functions in animal cells. It has been observed that currently confirmed C-type lectins share a highly conserved domain known as the C-type carbohydrate recognition domain (CRD). Using the sequence profile of the CRD, an increasing number of putative C-type lectins have been identified. Hence, it is highly needed to develop a systematic framework that enables us to elucidate their carbohydrate (glycan) recognition function, and discover their physiological and pathological roles.

Results

Presented herein is an integrated workflow for characterizing the sequence and structural features of novel C-type lectins. Our workflow utilizes web-based que

SUBMITTER: Koh G 

PROVIDER: S-EPMC3287470 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature