Combinatorial motif analysis of regulatory gene expression in Mafb deficient macrophages.

ABSTRACT:

Background

Deficiency of the transcription factor MafB, which is normally expressed in macrophages, can underlie cellular dysfunction associated with a range of autoimmune diseases and arteriosclerosis. MafB has important roles in cell differentiation and regulation of target gene expression; however, the mechanisms of this regulation and the identities of other transcription factors with which MafB interacts remain uncertain. Bioinformatics methods provide a valuable approach for elucidating the nature of these interactions with transcriptional regulatory elements from a large number of DNA sequences. In particular, identification of patterns of co-occurrence of regulatory cis-elements (motifs) offers a robust approach.

Results

Here, the directional relationships among seve

SUBMITTER: Morita M 

PROVIDER: S-EPMC3287487 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature