Exploring virus relationships based on virus-host protein-protein interaction network.

ABSTRACT:

Background

Currently, several systems have been proposed to classify viruses and indicate the relationships between different ones, though each system has its limitations because of the complexity of viral origins and their rapid evolution rate. We hereby propose a new method to explore the relationships between different viruses.

Method

A new method, which is based on the virus-host protein-protein interaction network, is proposed in this paper to categorize viruses. The distances between 114 human viruses, including 48 HIV-1 and HIV-2 viruses, are estimated according to the protein-protein interaction network between these viruses and humans.

Conclusions/significance

The results demonstrated that our method can disclose not only relationships consistent with the tax

SUBMITTER: Xu F 

PROVIDER: S-EPMC3287566 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature