An integrative analysis of DNA methylation and RNA-Seq data for human heart, kidney and liver.

ABSTRACT:

Background

Many groups, including our own, have proposed the use of DNA methylation profiles as biomarkers for various disease states. While much research has been done identifying DNA methylation signatures in cancer vs. normal etc., we still lack sufficient knowledge of the role that differential methylation plays during normal cellular differentiation and tissue specification. We also need thorough, genome level studies to determine the meaning of methylation of individual CpG dinucleotides in terms of gene expression.

Results

In this study, we have used (insert statistical method here) to compile unique DNA methylation signatures from normal human heart, lung, and kidney using the Illumina Infinium 27 K methylation arrays and compared those to gene expression by RNA sequ

SUBMITTER: Xie L 

PROVIDER: S-EPMC3287572 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature