Molecular dynamics study of the archaeal aquaporin AqpM.

ABSTRACT:

Background

Aquaporins are a large family of transmembrane channel proteins that are present throughout all domains of life and are implicated in human disorders. These channels, allow the passive but selective movement of water and other small neutral solutes across cell membranes. Aquaporins have been classified into two sub-families: i) strict aquaporins that only allow the passage of water and ii) the less selective aquaglyceroporins that transport water and other neutral solutes, such as glycerol, CO2 or urea. Recently, the identification and characterization of a number of archaeal and bacterial aquaporins suggested the existence of a third sub-family; one that is neither a strict aquaporin nor an aquaglyceroporin. The function and phylogeny of this third family is still a mat

SUBMITTER: Araya-Secchi R 

PROVIDER: S-EPMC3287591 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature