Effects of genome-wide copy number variation on expression in mammalian cells.

ABSTRACT:

Background

There is only a limited understanding of the relation between copy number and expression for mammalian genes. We fine mapped cis and trans regulatory loci due to copy number change for essentially all genes using a human-hamster radiation hybrid (RH) panel. These loci are called copy number expression quantitative trait loci (ceQTLs).

Results

Unexpected findings from a previous study of a mouse-hamster RH panel were replicated. These findings included decreased expression as a result of increased copy number for 30% of genes and an attenuated relationship between expression and copy number on the X chromosome suggesting an Xist independent form of dosage compensation. In a separate glioblastoma dataset, we found conservation of genes in which dosage was negatively

SUBMITTER: Wang RT 

PROVIDER: S-EPMC3287593 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature