Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.

ABSTRACT:

Purpose

Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents.

Experimental design

Creatinine transport was studied in transfected HEK293 cells in vitro and in wild-type mice and age-matched organic cation transporter 1 and 2-deficient [Oct1/2(-/-)] mice ex vivo and in vivo. Clinical pharmacogenetic and transport inhibition studies were done in two separate cohorts of cancer patients.

Results

Compared with wild-type mice, creatinine clearance was significantly impaired in Oct1/2(-/-) mice. Furthermore, creatinine inhibited organic cation transport in freshly isolated proximal tubules f

SUBMITTER: Ciarimboli G 

PROVIDER: S-EPMC3288323 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature