Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration.

ABSTRACT:

Purpose

To compare plasma levels of oxidative stress biomarkers in patients with age-related macular degeneration (AMD) and controls and to evaluate a potential relationship between biochemical markers of oxidative stress and AMD susceptibility genotypes.

Design

Prospective case-control study.

Methods

Plasma levels of oxidative stress biomarkers were determined in 77 AMD patients and 75 controls recruited from a clinical practice. Cysteine, cystine (CySS), glutathione, isoprostane, and isofuran were measured, and participants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes.

Results

CySS was elevated in cases compared with controls (P = .013). After adjustment for age, sex, and smoking,

SUBMITTER: Brantley MA 

PROVIDER: S-EPMC3288635 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature