Incremental value of biochemical and echocardiographic measures in prediction of ischemic stroke: the Strong Heart Study.

ABSTRACT:

Background and purpose

American Indians have high rates of stroke. Improved risk stratification could enhance prevention, but the ability of biochemical and echocardiographic markers of preclinical disease to improve stroke prediction is not well-defined.

Methods

We evaluated such markers as predictors of ischemic stroke in a community-based cohort of American Indians without prevalent cardiovascular or renal disease. Laboratory markers included C-reactive protein, fibrinogen, urine albumin-to-creatinine ratio, and glycohemoglobin (HbA1c), whereas echocardiographic parameters comprised left atrial diameter, left ventricular mass, mitral annular calcification, and the ratio of early to late mitral diastolic velocities. Predictive performance was judged by indices of discrimin

SUBMITTER: Karas MG 

PROVIDER: S-EPMC3288714 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature