Isoflurane post-conditioning protects against intestinal ischemia-reperfusion injury and multiorgan dysfunction via transforming growth factor-β1 generation.

ABSTRACT:

Objective

This study examined volatile anesthetic-mediated protection against intestinal ischemia-reperfusion injury (IRI).

Background

Intestinal IRI is a devastating complication in the perioperative period leading to systemic inflammation and multiorgan dysfunction. Volatile anesthetics, including isoflurane, have anti-inflammatory effects. We aimed to determine whether isoflurane, given after intestinal ischemia, protects against intestinal IRI and the mechanisms involved in this protection.

Methods

: After IACUC approval, mice were anesthetized with pentobarbital and subjected to 30 minutes of superior mesenteric artery ischemia, followed by 4 hours of equianesthetic doses of pentobarbital or isoflurane. Five hours after reperfusion, small intestine tissues were a

SUBMITTER: Kim M 

PROVIDER: S-EPMC3288790 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature