Hippocampal neurotransmitter efflux during one-trial novel object recognition in rats.

ABSTRACT: Several lines of evidence point to a role for the hippocampal formation and contiguous temporal lobe structures in a variety of learning and memory paradigms. Presumably, these cognitive phenomena are mediated (and accompanied) by dynamic changes in neurochemical transmission that may differ between learning and recall phases. However, the neurotransmitter correlates of most memory-related tasks have not been thoroughly investigated. Here we used a one-trial object recognition paradigm paired with in vivo microdialysis to assess hippocampal acetylcholine (ACh), glutamate and GABA efflux when rats were exposed to familiar objects, and when given the option to explore familiar and novel objects. Rats preferentially explored the novel object over the familiar one when presented with the optio

SUBMITTER: Stanley EM 

PROVIDER: S-EPMC3288804 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature