Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis.

ABSTRACT:

Objective

Sex disparities in rheumatoid arthritis (RA) are well documented despite the lack of any known major RA susceptibility genes mapped to sex chromosomes. Murine chromosome 15 carries the sex-affected Pgia8 locus that mediates proteoglycan-induced arthritis, and homologous human loci are associated with RA. This study was undertaken to identify genes/mechanisms implicated in sex disparities in arthritis.

Methods

Gene expression analysis was performed using RNA isolated from the paws of male and female Pgia8-congenic mice with collagen antibody-induced arthritis. Results were corroborated by reverse transcription-polymerase chain reaction, and mice were also studied prior to disease onset. Ingenuity Pathways Analysis of the expression patterns and gene functions was us

SUBMITTER: Kudryavtseva E 

PROVIDER: S-EPMC3288823 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature