NWE: Node-weighted expansion for protein complex prediction using random walk distances.

ABSTRACT:

Background

Protein complexes are important entities to organize various biological processes in the cell, like signal transduction, gene expression, and molecular transmission. In most cases, proteins perform their intrinsic tasks in association with their specific interacting partners, forming protein complexes. Therefore, an enriched catalog of protein complexes in a cell could accelerate further research to elucidate the mechanisms underlying many biological processes. However, known complexes are still limited. Thus, it is a challenging problem to computationally predict protein complexes from protein-protein interaction networks, and other genome-wide data sets.

Methods

Macropol et al. proposed a protein complex prediction algorithm, called RRW, which repeatedly expands

SUBMITTER: Maruyama O 

PROVIDER: S-EPMC3289075 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature