Why not consider a spherical protein? Implications of backbone hydrogen bonding for protein structure and function.

ABSTRACT: The intrinsic ability of protein structures to exhibit the geometric features required for molecular function in the absence of evolution is examined in the context of three systems: the reference set of real, single domain protein structures, a library of computationally generated, compact homopolypeptides, artificial structures with protein-like secondary structural elements, and quasi-spherical random proteins packed at the same density as proteins but lacking backbone secondary structure and hydrogen bonding. Without any evolutionary selection, the library of artificial structures has similar backbone hydrogen bonding, global shape, surface to volume ratio and statistically significant structural matches to real protein global structures. Moreover, these artificial structures have nati

SUBMITTER: Brylinski M 

PROVIDER: S-EPMC3289135 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature