An FMRI study of the effects of psychostimulants on default-mode processing during Stroop task performance in youths with ADHD.

ABSTRACT:

Objective

The authors examined the effect of psychostimulants on brain activity in children and adolescents with ADHD performing the Stroop Color and Word Test.

Method

The authors acquired 52 functional MRI scans in 16 youths with ADHD who were known responders to stimulant medication and 20 healthy comparison youths. Participants with ADHD were scanned on and off medication in a counterbalanced design, and comparison subjects were scanned once without medication.

Results

Stimulant medication significantly improved suppression of default-mode activity in the ventral anterior cingulate cortex in the ADHD group. When off medication, youths with ADHD were unable to suppress default-mode activity to the same degree as comparison subjects, whereas when on medication, they

SUBMITTER: Peterson BS 

PROVIDER: S-EPMC3289412 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature