Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.

ABSTRACT: Dengue viruses (DENV) are enveloped single-stranded positive-sense RNA viruses transmitted by Aedes spp. mosquitoes. There are four genetically distinct serotypes designated DENV-1 through DENV-4, each further subdivided into distinct genotypes. The dengue scientific community has long contended that infection with one serotype confers lifelong protection against subsequent infection with the same serotype, irrespective of virus genotype. However this hypothesis is under increased scrutiny and the role of DENV genotypic variation in protection from repeated infection is less certain. As dengue vaccine trials move increasingly into field-testing, there is an urgent need to develop tools to better define the role of genotypic variation in DENV infection and immunity. To better understand gen

SUBMITTER: Messer WB 

PROVIDER: S-EPMC3289595 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature