PHACTS, a computational approach to classifying the lifestyle of phages.

ABSTRACT:

Motivation

Bacteriophages have two distinct lifestyles: virulent and temperate. The virulent lifestyle has many implications for phage therapy, genomics and microbiology. Determining which lifestyle a newly sequenced phage falls into is currently determined using standard culturing techniques. Such laboratory work is not only costly and time consuming, but also cannot be used on phage genomes constructed from environmental sequencing. Therefore, a computational method that utilizes the sequence data of phage genomes is needed.

Results

Phage Classification Tool Set (PHACTS) utilizes a novel similarity algorithm and a supervised Random Forest classifier to make a prediction whether the lifestyle of a phage, described by its proteome, is virulent or temperate. The similarity al

SUBMITTER: McNair K 

PROVIDER: S-EPMC3289917 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature