Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications.

ABSTRACT:

Objectives

Aneurysm diameter and growing rate does not represent a definite parameter for operation in bicuspid aortic valve (BAV), ascending aortic aneurysm and normal root patients. Thus, we investigated histological and immunohistochemical aspects of different segments of ascending aorta (precisely, aortic root without dilatation, aneurysmatic tubular portion, dissected ascending aorta) and genetic features of patients with BAV and ascending aorta complication (aneurysm or dissection).

Methods

Aorta tissue samples of 24 BAV patients were examined. The patients comprised of 18 men and 6 women; the mean age was 54.2 ± 14.3 years. All patients underwent composite aortic root replacement (button Bentall operation). Multiple histological sections were prepared from each aortic

SUBMITTER: Pisano C 

PROVIDER: S-EPMC3290383 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature