Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
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ABSTRACT:
SUBMITTER: McColl G
PROVIDER: S-EPMC3290589 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
McColl Gawain G James Simon A SA Mayo Sheridan S Howard Daryl L DL Ryan Christopher G CG Kirkham Robin R Moorhead Gareth F GF Paterson David D de Jonge Martin D MD Bush Ashley I AI
PloS one 20120229 2
Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack of methods for direct in situ visualization of Mn and other biological metals within intact multicellular eukaryotes limits our understanding of management of these metals. We provide the first quantitative subcellular visualization of endogenous Mn concentrations (spanning two orders of magnitude) associated with individual cells of the nematode, Caenorhabditis eleg ...[more]
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