Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target.

ABSTRACT: New antibiotics with novel modes of action are required to combat the growing threat posed by multi-drug resistant bacteria. Over the last decade, genome sequencing and other high-throughput techniques have provided tremendous insight into the molecular processes underlying cellular functions in a wide range of bacterial species. We can now use these data to assess the degree of conservation of certain aspects of bacterial physiology, to help choose the best cellular targets for development of new broad-spectrum antibacterials. DNA replication is a conserved and essential process, and the large number of proteins that interact to replicate DNA in bacteria are distinct from those in eukaryotes and archaea; yet none of the antibiotics in current clinical use acts directly on the replication

SUBMITTER: Robinson A 

PROVIDER: S-EPMC3290774 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature