Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent.

ABSTRACT: The degree to which the level of genetic variation for gene expression is shared across multiple tissues has important implications for research investigating the role of expression on the etiology of complex human traits and diseases. In the last few years, several studies have been published reporting the extent of overlap in expression quantitative trait loci (eQTL) identified in multiple tissues or cell types. Although these studies provide important information on the regulatory control of genes across tissues, their limited power means that they can typically only explain a small proportion of genetic variation for gene expression. Here, using expression data from monozygotic twins (MZ), we investigate the genetic control of gene expression in lymphoblastoid cell lines (LCL) and whol

SUBMITTER: Powell JE 

PROVIDER: S-EPMC3290781 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature