Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women.

ABSTRACT:

Aims/hypothesis

We have previously described differences in adipose cell size distribution and expression of genes related to adipocyte differentiation in subcutaneous abdominal fat obtained from insulin-sensitive (IS) and -resistant (IR) persons, matched for degree of moderate obesity. To determine whether other biological properties also differ between IR and IS obese individuals, we quantified markers of inflammatory activity in adipose tissue from overweight IR and IS individuals.

Methods

Subcutaneous abdominal tissue was obtained from moderately obese women, divided into IR (n = 14) and IS (n = 19) subgroups by determining their steady-state plasma glucose (SSPG) concentrations during the insulin suppression test. Inflammatory activity was assessed by comparing expressi

SUBMITTER: McLaughlin T 

PROVIDER: S-EPMC3290914 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature