Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

ABSTRACT:

Aims

Pulmonary arterial hypertension (PAH) is a progressive lung disease characterized by pulmonary vasoconstriction and vascular remodelling, leading to increased pulmonary vascular resistance and right heart failure. Loss of nitric oxide (NO) signalling and increased endothelial nitric oxide synthase (eNOS)-derived oxidative stress are central to the pathogenesis of PAH, yet the mechanisms involved remain incompletely determined. In this study, we investigated the role activated CD47 plays in promoting PAH.

Methods and results

We report high-level expression of thrombospondin-1 (TSP1) and CD47 in the lungs of human subjects with PAH and increased expression of TSP1 and activated CD47 in experimental models of PAH, a finding matched in hypoxic human and murine pulmonary end

SUBMITTER: Bauer PM 

PROVIDER: S-EPMC3291089 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature