Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials.

ABSTRACT:

Objective

To examine the feasibility and test-retest reliability of encoding-task functional magnetic resonance imaging (fMRI) in mild Alzheimer disease (AD).

Design

Randomized, double-blind, placebo-controlled study.

Setting

Memory clinical trials unit.

Participants

We studied 12 patients with mild AD (mean [SEM] Mini-Mental State Examination score, 24.0 [0.7]; mean Clinical Dementia Rating score, 1.0) who had been taking donepezil hydrochloride for more than 6 months from the placebo arm of a larger 24-week study (n = 24, 4 scans on weeks 0, 6, 12, and 24, respectively).

Interventions

Placebo and 3 face-name, paired-associate encoding, block-design blood oxygenation level-dependent fMRI scans in 12 weeks.

Main outcome measures

We performed whole

SUBMITTER: Atri A 

PROVIDER: S-EPMC3291175 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature