Cancer gene prioritization for targeted resequencing using FitSNP scores.

ABSTRACT:

Background

Although the throughput of next generation sequencing is increasing and at the same time the cost is substantially reduced, for the majority of laboratories whole genome sequencing of large cohorts of cancer samples is still not feasible. In addition, the low number of genomes that are being sequenced is often problematic for the downstream interpretation of the significance of the variants. Targeted resequencing can partially circumvent this problem; by focusing on a limited number of candidate cancer genes to sequence, more samples can be included in the screening, hence resulting in substantial improvement of the statistical power. In this study, a successful strategy for prioritizing candidate genes for targeted resequencing of cancer genomes is presented.

Results

SUBMITTER: Fieuw A 

PROVIDER: S-EPMC3291573 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature