Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes.

ABSTRACT:

Objective

Leptin therapy improves insulin sensitivity in people with leptin deficiency, but it is not known whether it improves insulin action in people who are not leptin deficient. The purpose of the current study was to determine whether leptin treatment has weight loss-independent effects on insulin action in obese subjects with type 2 diabetes.

Research design and methods

We conducted a randomized, placebo-controlled trial in obese subjects (BMI: 35.4 ± 0.6 kg/m(2); mean ± SE) with newly diagnosed type 2 diabetes. Subjects were randomized to treatment with placebo (saline), low-dose (30 mg/day), or high-dose (80 mg/day) recombinant methionyl human (r-Met hu) leptin for 14 days. Multiorgan insulin sensitivity before and after treatment was evaluated by using the hyperins

SUBMITTER: Mittendorfer B 

PROVIDER: S-EPMC3292320 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature