Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling.

ABSTRACT:

Background

TF is highly expressed in cancerous and atherosclerotic lesions. Monocyte recruitment is a hallmark of disease progression in these pathological states.

Objective

To examine the role of integrin signaling in TF-dependent recruitment of monocytes by endothelial cells.

Methods

The expression of flTF and asTF in cervical cancer and atherosclerotic lesions was examined. Biologic effects of the exposure of primary microvascular endothelial cells (MVEC) to truncated flTF ectodomain (LZ-TF) and recombinant asTF were assessed.

Results

flTF and asTF exhibited nearly identical expression patterns in cancer lesions and lipid-rich plaques. Tumor lesions, as well as stromal CD68(+)  monocytes/macrophages, expressed both TF forms. Primary MVEC rapidly adhered to a

SUBMITTER: Srinivasan R 

PROVIDER: S-EPMC3292430 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature