TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data.

ABSTRACT:

Background

Locus heterogeneity is one of the most documented phenomena in genetics. To date, relatively little work had been done on the development of methods to address locus heterogeneity in genetic association analysis. Motivated by Zhou and Pan's work, we present a mixture model of linked and unlinked trios and develop a statistical method to estimate the probability that a heterozygous parent transmits the disease allele at a di-allelic locus, and the probability that any trio is in the linked group. The purpose here is the development of a test that extends the classic transmission disequilibrium test (TDT) to one that accounts for locus heterogeneity.

Results

Our simulations suggest that, for sufficiently large sample size (1000 trios) our method has good power to de

SUBMITTER: Londono D 

PROVIDER: S-EPMC3292499 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature