Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics.

ABSTRACT:

Background

Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics have not been well investigated in most invertebrates. Here, we performed genome survey for key defensome genes in Oikopleura dioica genome, and explored genome-wide gene expression using high density tiling arrays with over 2 million probes, in response to two model xenobiotic chemicals - the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) the pharmaceutical compound Clofibrate (Clo).

Results

Oikopleura genome surveys for key genes of the chemical defensome suggested a reduced repertoire. Not more than

SUBMITTER: Yadetie F 

PROVIDER: S-EPMC3292500 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature