Biophysical and structural considerations for protein sequence evolution.

ABSTRACT:

Background

Protein sequence evolution is constrained by the biophysics of folding and function, causing interdependence between interacting sites in the sequence. However, current site-independent models of sequence evolutions do not take this into account. Recent attempts to integrate the influence of structure and biophysics into phylogenetic models via statistical/informational approaches have not resulted in expected improvements in model performance. This suggests that further innovations are needed for progress in this field.

Results

Here we develop a coarse-grained physics-based model of protein folding and binding function, and compare it to a popular informational model. We find that both models violate the assumption of the native sequence being close to a thermody

SUBMITTER: Grahnen JA 

PROVIDER: S-EPMC3292521 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature